Interstate 89 is arguably one of Vermont's most important roads, as it is the only Interstate highway to directly serve both Vermont's capital city (Montpelier) and largest city (Burlington), as well as providing the fastest link between the two. Other important cities and towns located along I-89 are Barre, Waterbury, and St. Albans. Williston, which has become Burlington's "big-box" retail center (and one of the fastest-growing towns in the state) over the past decade, also has an interchange along I-89.
Crossing the Connecticut River into Vermont, I-89 continues the northwesterly direction it carried in New Hampshire. The Interstate intersects I-91 at an unnumbered interchange immediately upon entering Vermont. Shortly afterward, another interchange with U.S. 4 occurs. The highway begins to enter the scenic rolling hills of Vermont, turning almost due northward about 20 miles (32 kilometres) from the New Hampshire state line, and continues through the high country of central Vermont. The Interstate passes through the towns of Sharon, Royalton, Bethel, Randolph, Brookfield, and Williamstown before reaching the "twin cities" of Barre and Montpelier in the middle of Vermont. The interstate's highest point was said to be in the town of Brookfield, although the sign stating this was taken down in the late 1990s.
Another directional shift, again to the northwest, occurs while passing the interchange for Montpelier. For the next 40 miles (64 kilometres), I-89's path isn't so much chosen as it is logical: paralleling the Winooski River and U.S. Route 2, the highway cuts through the section of the Appalachians known as the Green Mountains, and is surrounded by peaks of over 4,000 feet (1,219 metres), such as Camel's Hump. U.S. Route 2 crosses the Interstate frequently, and has several interchanges with it, en route to Burlington.
Interstate 89 is unique due to one instance of its signage. Just beyond (Vermont) Exit 9 on both sides of the highway, about 10 miles (16 kilometres) north of Montpelier, signs showing the distance to the next control cities are completely in metric. While there are many instances of signs being in both miles and kilometres, this is the only case of solely metric in the entire Interstate System.[3] Interstate 19 in Arizona used to be the other "only signed in metric" interstate in the U.S., but has been changed over in recent years as the last 2 km have been changed. Speed limit signs have always been in mph.
After Exit 11 in Richmond, I-89 leaves the Green Mountains to enter the Champlain Valley and a notable shift in the landscape is visible. Here, just outside of Burlington, the highway turns northward once again. Also, at this turn is where the only official auxiliary highway starts, Interstate 189. A second highway, Interstate 289, was proposed as a beltway through Burlington's northeastern suburbs in the 1980s; amidst controversy, the highway has only been partially completed as Vermont Route 289, a Super two roadway. It has yet to directly meet its parent.
Passing I-189, I-89 sees the busiest freeway interchange in the entire state, Exit 14. A full cloverleaf interchange at this exit provides access to downtown Burlington, the University of Vermont, and the retail-heavy Dorset Street, via U.S. Route 2. Heading north from Burlington, the landscape quickly fades from suburban development into rolling hills more characteristic of northern New England, providing a vista overlooking Lake Champlain. I-89 passes through Milton, Georgia, St. Albans, Swanton, and finally the border town of Highgate Springs. The highway ends at the Canadian border in Highgate Springs. Its final exit, which northbound motorists can use to reverse direction onto I-89 south without crossing the border, is Exit 22 - the highest exit number along the route. U.S. Route 7 has its northern terminus at this interchange as well.
Although the divided highway continues about 5 miles (8 kilometres) into Phillipsburg, Quebec as Route 133, this changes back to a two-lane road, until Autoroute 35 starts outside of St. Jean, Quebec, and continues to Montreal. The I-89 border crossing is the only instance where an Interstate entering Quebec does not become an Autoroute upon entering the Canadian province. However, Autoroute 35 will be extended in the next few years, creating a freeway-to-freeway connection.